Ulcerogenic activity of celecoxib, piroxicam and piroxicam associated with zinc sulfate in granuloma model in rats
DOI:
https://doi.org/10.5585/conssaude.v9i1.2059Keywords:
Antiinflamatórios não esteróides, Celecoxibe, Piroxicam, Úlcera, Zinco.Abstract
OBJECTIVES: The aim of this study was to evaluate the ulcerogenic activity of celecoxib (selective COX-2), the piroxicam and piroxicam + zinc sulfate (nonselective NSAIDs). METHOD: It has been utilized introduction of cotton pellets in the abdominal region of rats, and by evaluating the formation of gastric lesions promoted by the model. RESULTS: The results showed that granuloma formation did not induce gastric lesions. CONCLUSIONS: Among the drugs studied, there was a higher incidence of gastric lesions caused by piroxicam when compared with celecoxib, while the association piroxicam + zinc sulfate had lower gastric lesion, when compared to piroxicam.Downloads
Download data is not yet available.
Downloads
Published
2010-06-17
How to Cite
1.
Bueno J do A, Boiati RF, de Menezes FG, Nascimento JWL. Ulcerogenic activity of celecoxib, piroxicam and piroxicam associated with zinc sulfate in granuloma model in rats. Cons. Saúde [Internet]. 2010 Jun. 17 [cited 2024 Sep. 19];9(1):79-86. Available from: https://uninove.emnuvens.com.br/saude/article/view/2059
Issue
Section
Applied Sciences
License
Copyright (c) 2010 ConScientiae Saúde
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.